Positive regulation of double-strand break repair

Across TCGA cell cohorts, RNA activity of the Positive regulation of double-strand break repair pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OVOL1, HBP1, and HHEX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OVOL1 grouped by Positive regulation of double-strand break repair-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OVOL1 →	+1.534	+0.145	.003	.002	3	5
UPPER_AERODIGESTIVE_TRACT	HBP1 →	+0.974	+0.151	<.001	.007	3	4
URINARY_TRACT	HHEX →	-2.917	-0.273	.007	.006	3	4
KIDNEY	JARID2 →	+0.824	+0.208	.008	.006	3	4
LUNG_NSCLC_LUSC	PRCP →	-1.276	-0.156	.004	.002	3	4
LUNG_NSCLC_LUAD	FUT3 →	+2.117	+0.166	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OVOL1 by Positive regulation of double-strand break repair activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →