Positive regulation of double-strand break repair

Across TCGA cell cohorts, RNA activity of the Positive regulation of double-strand break repair pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTSL5, AVPI1, and KDM1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of double-strand break repair activity versus ADAMTSL5 in OESOPHAGUS (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ADAMTSL5 →	-1.588	-0.172	.003	.005	2	8
OVARY	AVPI1 →	-1.818	-0.190	<.001	<.001	3	7
LUNG_NSCLC_LUAD	KDM1A →	+0.631	+0.171	<.001	<.001	3	6
LUNG_SCLC	SYDE1 →	-1.685	-0.251	.008	<.001	3	6
SOFT_TISSUE	CREB3L4 →	+0.707	+0.248	<.001	<.001	3	6
BREAST	ZNF821 →	+0.820	+0.170	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000781 vs ADAMTSL5 — OESOPHAGUS

Explore this scatter interactively →