Regulation of double-strand break repair

Across TCGA patient cohorts, RNA activity of the Regulation of double-strand break repair pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS2, BTK, and ARHGDIB, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of double-strand break repair activity versus LGALS2 in OV (Pearson r = -0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LGALS2 →	-1.651	-1.050	<.001	<.001	3	2
OV	BTK →	-1.932	-1.380	<.001	<.001	3	2
OV	ARHGDIB →	-2.048	-1.227	.001	<.001	3	2
OV	KYNU →	-0.874	-1.044	<.001	.002	3	2
OV	KMO →	-0.803	-1.182	<.001	<.001	3	2
OV	MFSD1 →	-1.091	-1.148	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000779 vs LGALS2 — OV

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