Regulation of double-strand break repair

Across TCGA cell cohorts, RNA activity of the Regulation of double-strand break repair pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARID1A, RERE, and RSBN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of double-strand break repair activity versus ARID1A in BREAST (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ARID1A →	+1.200	+0.221	<.001	<.001	3	7
STOMACH	RERE →	+1.587	+0.309	<.001	.001	3	6
STOMACH	RSBN1 →	+0.754	+0.252	.002	<.001	3	6
OVARY	AVPI1 →	-1.684	-0.215	<.001	<.001	3	6
BLOOD_Lymphoma	HEXB →	-1.749	-0.145	.006	.002	3	6
BLOOD_Leukemia	POU2F1 →	+0.777	+0.170	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000779 vs ARID1A — BREAST

Explore this scatter interactively →