Positive regulation of cellular senescence

Across TCGA patient cohorts, RNA activity of the Positive regulation of cellular senescence pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP4, SIPA1, and KIAA1671, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular senescence activity versus ARHGAP4 in COAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ARHGAP4 →	+0.370	+0.039	<.001	<.001	3	7
COAD	SIPA1 →	+0.291	+0.038	<.001	<.001	3	6
OV	KIAA1671 →	-0.262	-0.033	.001	.006	3	5
LUAD	RCSD1_S216 →	+0.720	+0.036	.001	.002	3	5
GBM	INPP5D →	+0.571	+0.068	<.001	<.001	3	5
COAD	ADGRE2 →	+0.565	+0.041	.009	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000774 vs ARHGAP4 — COAD

Explore this scatter interactively →