Positive regulation of cellular senescence

Across TCGA patient cohorts, RNA activity of the Positive regulation of cellular senescence pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGHV3-21, ADAMTS7P4, and HTRA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cellular senescence activity versus IGHV3-21 in LUAD (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IGHV3-21 →	+1.049	+0.366	<.001	.001	3	4
LUAD	ADAMTS7P4 →	+0.154	+0.330	.004	.003	3	4
BRCA	HTRA4 →	+0.606	+0.747	.002	.001	3	4
BRCA	CD38 →	+1.246	+0.639	<.001	.006	3	4
PDAC	NQO2 →	+0.223	+0.297	.007	.001	3	3
PDAC	LINC02066 →	+0.480	+0.348	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000774 vs IGHV3-21 — LUAD

Explore this scatter interactively →