Regulation of cellular senescence

Across TCGA patient cohorts, RNA activity of the Regulation of cellular senescence pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLGLB2, NDC80, and OR11H4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular senescence activity versus PLGLB2 in CCRCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PLGLB2 →	+0.270	+0.381	.001	.009	3	4
GBM	NDC80 →	+0.570	+0.537	.003	<.001	3	4
LSCC	OR11H4 →	+0.570	+0.595	.002	<.001	3	3
UCEC	CCDC150 →	+0.753	+1.078	<.001	<.001	3	3
UCEC	MTFR2 →	+0.782	+1.225	<.001	<.001	3	3
COAD	WNT2 →	+0.449	+0.160	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000772 vs PLGLB2 — CCRCC

Explore this scatter interactively →