Regulation of cellular senescence

Across TCGA cell cohorts, RNA activity of the Regulation of cellular senescence pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX25, FN1, and SNX9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNX25 grouped by Regulation of cellular senescence-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SNX25 →	-1.093	-0.211	.002	.003	3	3
LUNG_NSCLC_LUSC	FN1 →	-3.700	-0.218	.003	.002	3	3
LUNG_NSCLC_LUSC	SNX9 →	-1.091	-0.294	.002	.002	3	3
LUNG_NSCLC_LUSC	CFLAR →	-1.400	-0.220	.002	.002	3	3
OESOPHAGUS	ILF3 →	+0.502	+0.168	.005	.005	3	3
OESOPHAGUS	IGFBP3 →	-3.816	-0.160	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNX25 by Regulation of cellular senescence activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →