Positive regulation of cytoplasmic translation

Across TCGA patient cohorts, RNA activity of the Positive regulation of cytoplasmic translation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, ZCCHC24, and QKI, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoplasmic translation activity versus UCHL1 in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UCHL1 →	+1.201	+0.066	<.001	<.001	3	6
LUAD	ZCCHC24 →	+0.275	+0.055	.001	.001	3	6
BRCA	QKI →	+0.268	+0.049	<.001	<.001	3	6
CCRCC	SPAG9_S251 →	-0.428	-0.049	<.001	<.001	3	6
CCRCC	CACNA2D1 →	+0.394	+0.048	<.001	<.001	3	6
UCEC	JPT2 →	-0.470	-0.152	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000767 vs UCHL1 — BRCA

Explore this scatter interactively →