Positive regulation of cytoplasmic translation

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytoplasmic translation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSBP4, RTN4IP1, and MCM6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytoplasmic translation activity versus SSBP4 in BONE (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SSBP4 →	+2.167	+0.370	<.001	.001	3	7
OVARY	RTN4IP1 →	+1.013	+0.265	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	MCM6 →	+1.290	+0.279	.007	.006	2	8
KIDNEY	PA2G4 →	+0.948	+0.277	.002	.001	3	7
LIVER	POP7 →	+0.697	+0.281	<.001	.004	3	7
PANCREAS	RUVBL1 →	+1.078	+0.257	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000767 vs SSBP4 — BONE

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