Regulation of cytoplasmic translation

Across TCGA cell cohorts, RNA activity of the Regulation of cytoplasmic translation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAK16, METTL21A, and ELAC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cytoplasmic translation activity versus MAK16 in LARGE_INTESTINE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAK16 →	+1.119	+0.244	<.001	<.001	3	7
LARGE_INTESTINE	METTL21A →	+0.770	+0.201	.002	.002	3	6
OVARY	ELAC2 →	+0.654	+0.216	.002	<.001	3	6
URINARY_TRACT	ZNF286B →	+1.548	+0.306	<.001	.004	3	6
PANCREAS	SRSF7 →	+0.467	+0.186	<.001	<.001	3	6
PANCREAS	ACTR2 →	+0.721	+0.208	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000765 vs MAK16 — LARGE_INTESTINE

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