Regulation of peptidyl-lysine acetylation

Across TCGA patient cohorts, RNA activity of the Regulation of peptidyl-lysine acetylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDAC2, SEC24A, and AHNAK_S5298, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-lysine acetylation activity versus HDAC2 in HNSC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HDAC2 →	+0.213	+0.061	.004	.008	3	6
HNSC	SEC24A →	-0.205	-0.055	.004	.001	2	6
OV	AHNAK_S5298 →	-0.792	-0.052	.001	<.001	3	5
LUAD	ADNP →	+0.213	+0.036	.004	.004	3	5
LUAD	GTF3C2 →	+0.131	+0.036	.002	.004	3	5
OV	RHBDF2_S385 →	-0.778	-0.064	.009	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000756 vs HDAC2 — HNSC

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