Regulation of peptidyl-lysine acetylation

Across TCGA cell cohorts, RNA activity of the Regulation of peptidyl-lysine acetylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF15, SIRT1, and DIP2B, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-lysine acetylation activity versus KLF15 in LUNG_SCLC (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KLF15 →	-1.173	-0.138	<.001	<.001	3	14
PANCREAS	SIRT1 →	+0.913	+0.123	.001	.004	2	15
SOFT_TISSUE	DIP2B →	+0.952	+0.106	<.001	<.001	3	11
BLOOD_Lymphoma	SMC3 →	+1.102	+0.092	<.001	<.001	3	11
LARGE_INTESTINE	PCGF6 →	+0.584	+0.097	.004	.003	3	11
STOMACH	CHUK →	+0.870	+0.148	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000756 vs KLF15 — LUNG_SCLC

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