Regulation of peptidyl-lysine acetylation

Across TCGA cell cohorts, RNA activity of the Regulation of peptidyl-lysine acetylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAF4L1, CDNF, and RARA, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-lysine acetylation activity versus DCAF4L1 in BREAST (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DCAF4L1 →	+0.399	+0.444	.002	.007	3	2
BREAST	CDNF →	-1.190	-0.571	.008	.004	3	2
BLOOD_Leukemia	RARA →	-1.435	-0.364	.006	.008	3	2
BLOOD_Leukemia	NDUFAF3 →	-1.065	-0.280	.003	.008	3	2
BLOOD_Leukemia	NAA38 →	-1.765	-0.280	.005	.008	3	2
LARGE_INTESTINE	ERMP1 →	-2.150	-0.285	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000756 vs DCAF4L1 — BREAST

Explore this scatter interactively →