Regulation of mesenchymal stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of mesenchymal stem cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOX6_S454, BRD3, and MAN2A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mesenchymal stem cell differentiation activity versus SOX6_S454 in LSCC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SOX6_S454 →	+1.032	+0.067	<.001	<.001	3	6
GBM	BRD3 →	+0.396	+0.142	<.001	<.001	3	6
GBM	MAN2A1 →	-0.368	-0.091	<.001	<.001	3	6
UCEC	PRELP →	+0.559	+0.080	.005	.008	3	6
HNSC	ISLR →	+0.472	+0.051	<.001	.005	3	6
CCRCC	LMNB2 →	+0.309	+0.093	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000739 vs SOX6_S454 — LSCC

Explore this scatter interactively →