Regulation of mesenchymal stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of mesenchymal stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX6, COMMD2, and DDX31, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mesenchymal stem cell differentiation activity versus SOX6 in GBM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOX6 →	+0.805	+0.789	<.001	<.001	3	5
BRCA	COMMD2 →	+0.437	+0.245	<.001	<.001	3	5
GBM	DDX31 →	+0.317	+0.844	<.001	<.001	3	5
GBM	RPRD1A →	+0.292	+0.788	.003	<.001	3	5
GBM	CCNT2-AS1 →	+0.413	+1.047	<.001	<.001	3	5
GBM	TCF3 →	+0.456	+0.748	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000739 vs SOX6 — GBM

Explore this scatter interactively →