Regulation of mesenchymal stem cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of mesenchymal stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K3, LY9, and PSRC1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mesenchymal stem cell differentiation activity versus MAP4K3 in LUNG_SCLC (Pearson r = 0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAP4K3 →	+0.506	+1.941	.007	<.001	3	2
LUNG_SCLC	LY9 →	+0.105	+2.046	.002	<.001	3	2
LUNG_SCLC	PSRC1 →	+1.036	+1.941	.005	<.001	3	2
LUNG_SCLC	ZNF577 →	+3.416	+1.941	.001	<.001	3	2
LUNG_SCLC	RBM47 →	+5.610	+2.108	<.001	.001	3	2
LUNG_SCLC	IGDCC3 →	+1.236	+1.941	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000739 vs MAP4K3 — LUNG_SCLC

Explore this scatter interactively →