Positive regulation of stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of stem cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDGFL3, NFIX, and AGO1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of stem cell differentiation activity versus HDGFL3 in CCRCC (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HDGFL3 →	+0.514	+0.076	<.001	<.001	3	7
LUAD	NFIX →	+0.400	+0.065	<.001	<.001	3	7
UCEC	AGO1 →	+0.352	+0.101	<.001	<.001	3	7
HNSC	SETMAR →	+0.478	+0.081	<.001	<.001	3	6
CCRCC	TGFB2 →	+0.894	+0.070	<.001	.002	3	6
LUAD	TLN2 →	+0.384	+0.075	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000738 vs HDGFL3 — CCRCC

Explore this scatter interactively →