Positive regulation of stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX6, C9orf106, and ACTG1P9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of stem cell differentiation activity versus SOX6 in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SOX6 →	+0.881	+0.479	<.001	.006	3	5
LUAD	C9orf106 →	-0.565	-0.600	.001	.004	3	4
COAD	ACTG1P9 →	-0.074	-0.166	<.001	<.001	3	4
UCEC	NCAPD2 →	+0.773	+0.608	<.001	<.001	3	4
GBM	FANCE →	+0.363	+0.458	<.001	<.001	3	4
UCEC	KIF20A →	+0.974	+0.536	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000738 vs SOX6 — LSCC

Explore this scatter interactively →