Negative regulation of stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of stem cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD1B, MSH6, and RNASEH2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell differentiation activity versus RPRD1B in COAD (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPRD1B →	+0.310	+0.037	<.001	<.001	3	5
HNSC	MSH6 →	+0.360	+0.066	.003	.002	3	4
PDAC	RNASEH2A →	+0.240	+0.032	.004	.001	3	4
HNSC	RNASEH2B →	+0.323	+0.072	.001	<.001	3	4
LSCC	BCL11A_S630 →	+1.012	+0.075	.006	<.001	3	4
LSCC	BCL11A_S86 →	+0.919	+0.066	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000737 vs RPRD1B — COAD

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