Negative regulation of stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of stem cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SUZ12_S583, XAB2, and EZH2_T487, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell differentiation activity versus SUZ12_S583 in LSCC (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SUZ12_S583 →	+0.627	+0.301	<.001	<.001	3	6
COAD	XAB2 →	+0.214	+1.232	.001	<.001	3	6
LSCC	EZH2_T487 →	+0.741	+0.265	<.001	<.001	3	6
GBM	SF3B1 →	+0.211	+0.398	<.001	<.001	3	5
GBM	SF3B2 →	+0.232	+0.528	<.001	<.001	3	5
GBM	SF3B6 →	+0.311	+0.670	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000737 vs SUZ12_S583 — LSCC

Explore this scatter interactively →