Negative regulation of stem cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of stem cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC39A8, CAB39, and ITGA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC39A8 grouped by Negative regulation of stem cell differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC39A8 →	+0.154	+0.144	.006	.003	2	6
LUNG_SCLC	CAB39 →	+0.386	+0.259	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ITGA1 →	-0.261	-0.129	.002	.003	3	4
SOFT_TISSUE	KMT2A →	+0.139	+0.095	.005	.002	3	4
URINARY_TRACT	FZD5 →	+0.208	+0.150	<.001	.008	2	5
PANCREAS	C1QTNF7 →	-0.133	-0.111	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC39A8 by Negative regulation of stem cell differentiation activity — OVARY

Explore this box plot interactively →