Negative regulation of stem cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMSB4X, BAIAP2L2, and KLHL8, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stem cell differentiation activity versus TMSB4X in STOMACH (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMSB4X →	+2.579	+0.254	.006	.001	3	11
LIVER	BAIAP2L2 →	-2.932	-0.182	.005	.006	3	5
PANCREAS	KLHL8 →	-0.679	-0.230	<.001	<.001	3	5
BLOOD_Leukemia	STX17 →	-0.987	-0.161	<.001	<.001	3	5
KIDNEY	VAV2 →	-1.374	-0.187	.001	<.001	3	5
CNS	TIGD7 →	-0.604	-0.116	.009	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000737 vs TMSB4X — STOMACH

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