Regulation of stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of stem cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DBN1, TMF1, and RBM47, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stem cell differentiation activity versus DBN1 in HNSC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DBN1 →	+0.357	+0.083	.001	<.001	3	7
LSCC	TMF1 →	-0.408	-0.060	<.001	<.001	3	7
GBM	RBM47 →	-0.454	-0.036	.001	.003	3	7
CCRCC	BRD3 →	+0.227	+0.036	<.001	<.001	3	6
BRCA	FKBP7 →	+0.626	+0.040	<.001	<.001	3	6
PDAC	MACROH2A2 →	+0.326	+0.035	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000736 vs DBN1 — HNSC

Explore this scatter interactively →