Regulation of stem cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARHSP1, CD2BP2, and GPALPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CARHSP1 grouped by Regulation of stem cell differentiation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CARHSP1 →	-1.224	-0.461	.001	.001	2	6
OVARY	CD2BP2 →	-0.485	-0.243	.003	.002	2	6
LUNG_NSCLC_LUAD	GPALPP1 →	-0.458	-0.163	<.001	.002	3	5
BLOOD_Myeloma	SLC52A2 →	-1.257	-0.275	.004	.004	3	4
LUNG_NSCLC_LUAD	SAP18 →	-0.464	-0.154	<.001	<.001	3	4
LUNG_SCLC	PLCD4 →	+0.698	+0.247	.009	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CARHSP1 by Regulation of stem cell differentiation activity — LIVER

Explore this box plot interactively →