Positive regulation of cardiac muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of cardiac muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGKV1D-12, CAMSAP2, and TRBV18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cardiac muscle cell differentiation activity versus IGKV1D-12 in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGKV1D-12 →	+1.258	+0.585	<.001	<.001	3	4
GBM	CAMSAP2 →	-0.428	-0.599	<.001	.001	3	4
GBM	TRBV18 →	+0.352	+0.406	<.001	.008	3	4
LSCC	CPNE5 →	+0.491	+0.700	<.001	<.001	3	4
LSCC	P2RY8 →	+0.808	+0.655	<.001	<.001	3	4
HNSC	BTLA →	+0.929	+0.736	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000727 vs IGKV1D-12 — LSCC

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