Positive regulation of cardiac muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of cardiac muscle cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP4, TGFB1, and KAT2A, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMP4 grouped by Positive regulation of cardiac muscle cell differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BMP4 →	-0.282	-1.481	.002	<.001	3	11
LUNG_SCLC	TGFB1 →	-0.234	-0.936	.003	.002	3	8
BONE	KAT2A →	-0.223	-1.414	.001	.001	3	8
BLOOD_Leukemia	MEF2C →	-0.602	-1.397	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	PMM1 →	-0.294	-1.798	.004	<.001	3	5
OESOPHAGUS	ALOX15B →	-0.229	-1.507	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMP4 by Positive regulation of cardiac muscle cell differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →