Negative regulation of cardiac muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of cardiac muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADPGK, SOX6_S411, and PPP1R12A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle cell differentiation activity versus ADPGK in PDAC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ADPGK →	-0.233	-0.062	.005	<.001	3	6
LSCC	SOX6_S411 →	+1.222	+0.107	<.001	<.001	3	5
COAD	PPP1R12A →	+0.251	+0.037	.005	.007	3	5
BRCA	MATN2 →	+0.628	+0.046	<.001	<.001	3	5
LSCC	MAN2A1 →	-0.274	-0.072	.001	<.001	3	5
LUAD	IGFBP5 →	+0.538	+0.054	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000726 vs ADPGK — PDAC

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