Negative regulation of cardiac muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of cardiac muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC63P1, SOX6, and RN7SL188P, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle cell differentiation activity versus SEC63P1 in PDAC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEC63P1 →	-0.459	-0.193	<.001	.001	3	5
LSCC	SOX6 →	+1.205	+0.368	<.001	<.001	3	4
LSCC	RN7SL188P →	+1.361	+0.301	<.001	<.001	3	4
LSCC	LYL1 →	-0.335	-0.264	.006	<.001	3	4
LSCC	ZNF180 →	+0.375	+0.267	<.001	<.001	3	4
LSCC	CARNMT1-AS1 →	+0.434	+0.230	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000726 vs SEC63P1 — PDAC

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