Negative regulation of cardiac muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MELTF, SAMHD1, and ATG4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MELTF grouped by Negative regulation of cardiac muscle cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MELTF →	-1.976	-1.013	.008	.003	3	4
KIDNEY	SAMHD1 →	-1.994	-1.265	<.001	.002	3	4
KIDNEY	ATG4A →	-1.012	-1.340	<.001	.001	3	4
SKIN	KIF2C →	+0.549	+0.932	.005	.004	3	4
UPPER_AERODIGESTIVE_TRACT	IFNGR2 →	+0.916	+1.188	.001	.003	3	3
BLOOD_Lymphoma	RASSF8 →	-1.509	-1.637	.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MELTF by Negative regulation of cardiac muscle cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →