Negative regulation of cardiac muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of cardiac muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNS4, GSDMC, and SEC11C, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cardiac muscle cell differentiation activity versus TNS4 in LUNG_NSCLC_LUAD (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TNS4 →	+3.206	+1.994	.002	.001	3	2
LUNG_NSCLC_LUAD	GSDMC →	+2.126	+1.994	.001	.001	3	2
LUNG_NSCLC_LUAD	SEC11C →	-1.403	-1.994	.005	.001	3	2
LUNG_NSCLC_LUAD	TXNRD3 →	+0.780	+1.994	<.001	.001	3	2
LUNG_NSCLC_LUAD	ZNF880 →	+3.130	+1.994	.003	.001	3	2
BREAST	GNAT2 →	+0.253	+1.871	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000726 vs TNS4 — LUNG_NSCLC_LUAD

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