Regulation of cardiac muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBI, REEP5, and UBE2O, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGFBI grouped by Regulation of cardiac muscle cell differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TGFBI →	-3.151	-0.765	.009	.007	3	5
BREAST	REEP5 →	-0.790	-0.592	.001	.007	3	5
LUNG_NSCLC_LUSC	UBE2O →	+0.678	+1.251	.009	.007	3	5
SOFT_TISSUE	ACAP3 →	-1.454	-1.654	<.001	<.001	3	4
SOFT_TISSUE	PPP1R12A →	-0.821	-1.193	.001	<.001	3	4
SOFT_TISSUE	WDR7 →	-0.702	-1.470	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGFBI by Regulation of cardiac muscle cell differentiation activity — SKIN

Explore this box plot interactively →