Regulation of cardiac muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFB1, TRAM2, and FZD7, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell differentiation activity versus TGFB1 in LUNG_NSCLC_LUSC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TGFB1 →	+2.107	+0.149	.004	.005	3	11
URINARY_TRACT	TRAM2 →	+1.806	+0.136	.001	.001	3	9
OVARY	FZD7 →	+1.512	+0.148	<.001	<.001	3	8
LIVER	MAP4K4 →	+1.468	+0.127	.001	.001	3	7
BREAST	ST3GAL2 →	+1.166	+0.113	.001	.004	3	7
LIVER	BMP4 →	+2.871	+0.110	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000725 vs TGFB1 — LUNG_NSCLC_LUSC

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