Regulation of cardiac muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MORC4, WASL, and NOP9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell differentiation activity versus MORC4 in BLOOD_Myeloma (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MORC4 →	+1.708	+1.520	.001	.001	3	6
BLOOD_Myeloma	WASL →	+0.762	+1.197	.001	.009	3	5
LUNG_SCLC	NOP9 →	+0.565	+1.072	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	MBNL3 →	+1.139	+1.866	.003	.002	3	4
BLOOD_Leukemia	CD96 →	+2.926	+0.559	<.001	.008	3	4
CNS	TMEM183A →	+0.498	+0.588	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000725 vs MORC4 — BLOOD_Myeloma

Explore this scatter interactively →