Regulation of epithelial cell differentiation involved in kidney development

Across TCGA patient cohorts, RNA activity of the Regulation of epithelial cell differentiation involved in kidney development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL, REXO1_S358, and TTC7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial cell differentiation involved in kidney development activity versus VCL in PDAC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VCL →	+0.397	+0.231	<.001	<.001	3	5
GBM	REXO1_S358 →	-0.637	-0.299	<.001	<.001	3	4
GBM	TTC7A →	+0.331	+0.262	<.001	<.001	3	4
PDAC	FLNA_T2599 →	+0.806	+0.222	<.001	<.001	3	4
PDAC	YAP1_S382 →	+0.416	+0.141	<.001	<.001	3	4
BRCA	SLTM →	-0.222	-0.151	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000696 vs VCL — PDAC

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