Regulation of epithelial cell differentiation involved in kidney development

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial cell differentiation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD24, POLR3G, and PATJ, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial cell differentiation involved in kidney development activity versus CD24 in KIDNEY (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CD24 →	+4.679	+0.237	<.001	.005	3	13
OVARY	POLR3G →	-1.776	-0.195	<.001	.006	3	8
OVARY	PATJ →	+1.175	+0.250	<.001	<.001	3	8
PANCREAS	TSPAN13 →	+1.478	+0.196	<.001	<.001	3	7
OVARY	CRB3 →	+2.481	+0.233	<.001	<.001	3	7
PANCREAS	EXOSC2 →	-0.783	-0.138	.004	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000696 vs CD24 — KIDNEY

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