Regulation of epithelial cell differentiation involved in kidney development

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial cell differentiation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL19, KCNQ4, and IRF9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial cell differentiation involved in kidney development activity versus RPL19 in LUNG_SCLC (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RPL19 →	-0.878	-1.257	.001	.001	3	3
LUNG_SCLC	KCNQ4 →	-1.502	-1.082	.002	<.001	3	3
LUNG_SCLC	IRF9 →	+1.378	+1.200	.006	.003	3	3
LUNG_SCLC	ACACA →	-0.974	-1.184	<.001	.003	3	3
OVARY	IL15RA →	+2.435	+0.300	.001	.009	3	3
URINARY_TRACT	NDOR1 →	-0.603	-0.209	.007	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000696 vs RPL19 — LUNG_SCLC

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