Regulation of transcription regulatory region DNA binding

Across TCGA patient cohorts, RNA activity of the Regulation of transcription regulatory region DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNMA3, CAND2, and RAB6B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transcription regulatory region DNA binding activity versus PNMA3 in GBM (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PNMA3 →	-0.784	-0.474	.003	.005	3	4
HNSC	CAND2 →	-0.675	-0.501	.003	.001	3	3
LUAD	RAB6B →	-0.598	-0.597	.002	.002	3	3
HNSC	CMYA5 →	-1.368	-0.532	.003	.001	3	3
CCRCC	ARMCX2 →	-0.352	-0.463	.001	.005	3	3
LSCC	CHRDL1 →	-0.864	-0.168	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000677 vs PNMA3 — GBM

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