Regulation of transcription regulatory region DNA binding

Across TCGA cell cohorts, RNA activity of the Regulation of transcription regulatory region DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM268, TMEM45A, and FAM222A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM268 grouped by Regulation of transcription regulatory region DNA binding-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TMEM268 →	+1.027	+1.200	<.001	.001	3	4
OESOPHAGUS	TMEM45A →	+1.587	+0.597	.001	.005	3	4
BREAST	FAM222A →	+1.517	+0.995	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PMPCA →	+0.983	+0.988	.009	.009	3	4
STOMACH	NAF1 →	-0.608	-0.994	.001	.004	3	4
BREAST	CCDC40 →	+1.140	+0.629	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM268 by Regulation of transcription regulatory region DNA binding activity — PANCREAS

Explore this box plot interactively →