Regulation of transcription regulatory region DNA binding

Across TCGA cell cohorts, RNA activity of the Regulation of transcription regulatory region DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H1-0, RASA4B, and TDRKH, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transcription regulatory region DNA binding activity versus H1-0 in SKIN (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	H1-0 →	+3.514	+1.114	<.001	<.001	3	10
LUNG_SCLC	RASA4B →	+0.944	+0.146	.002	.001	3	4
LIVER	TDRKH →	+1.025	+0.221	.001	.001	3	4
CNS	C1GALT1 →	+1.376	+0.868	<.001	.004	2	5
CNS	RAPH1 →	+1.396	+0.916	<.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	PRKAG1 →	-0.878	-0.237	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000677 vs H1-0 — SKIN

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