Negative regulation of type B pancreatic cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of type B pancreatic cell apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASNS, CAVIN3, and CYGB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type B pancreatic cell apoptotic process activity versus ASNS in BRCA (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASNS →	-0.647	-0.042	.001	.002	3	7
BRCA	CAVIN3 →	+0.464	+0.050	<.001	<.001	3	7
OV	CYGB →	+0.575	+0.084	.001	.002	3	7
BRCA	FERMT2 →	+0.535	+0.058	.002	<.001	3	7
LSCC	HSPG2 →	+0.452	+0.058	<.001	.001	3	7
UCEC	JPT1 →	-0.475	-0.096	.003	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000675 vs ASNS — BRCA

Explore this scatter interactively →