Negative regulation of type B pancreatic cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of type B pancreatic cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAST, PGBD1, and TMEM97, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type B pancreatic cell apoptotic process activity versus CAST in LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CAST →	+0.544	+0.287	<.001	<.001	3	4
LUAD	PGBD1 →	-0.433	-0.197	.001	.001	3	4
HNSC	TMEM97 →	-0.879	-0.604	.005	.005	3	3
HNSC	PDE3B →	-0.688	-0.582	.001	.001	3	3
HNSC	CCDC138 →	-0.633	-0.647	.005	.002	3	3
HNSC	CST6 →	+1.282	+0.609	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000675 vs CAST — LUAD

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