Negative regulation of type B pancreatic cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of type B pancreatic cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAST, PTK6, and RNF223, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type B pancreatic cell apoptotic process activity versus CAST in BLOOD_Lymphoma (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CAST →	+2.148	+0.248	<.001	<.001	3	6
BLOOD_Lymphoma	PTK6 →	+2.066	+0.248	<.001	<.001	3	6
LUNG_NSCLC_LUAD	RNF223 →	+1.527	+0.195	<.001	.003	3	5
OVARY	EDA →	-1.032	-0.172	.002	.002	3	4
UPPER_AERODIGESTIVE_TRACT	CACNA1D →	+0.395	+0.306	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PCBD1 →	+1.405	+0.332	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000675 vs CAST — BLOOD_Lymphoma

Explore this scatter interactively →