Negative regulation of dendritic cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of dendritic cell apoptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2L1, CLPTM1L, and ACVR2A, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCL2L1 grouped by Negative regulation of dendritic cell apoptotic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	BCL2L1 →	-1.259	-1.896	<.001	.001	3	18
BLOOD_Myeloma	CLPTM1L →	-0.430	-1.953	.003	<.001	2	10
LIVER	ACVR2A →	-0.226	-1.331	.005	.007	3	5
LARGE_INTESTINE	HBA1 →	+0.202	+1.327	.001	.002	3	5
CNS	ICAM4 →	-0.275	-1.154	.009	.002	3	4
CNS	SLC27A6 →	+0.174	+0.890	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCL2L1 by Negative regulation of dendritic cell apoptotic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →