Negative regulation of dendritic cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of dendritic cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRTCAP2, COTL1, and RNPEP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KRTCAP2 grouped by Negative regulation of dendritic cell apoptotic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KRTCAP2 →	-0.662	-1.204	.001	.001	3	4
LUNG_NSCLC_LUSC	COTL1 →	-2.782	-1.325	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RNPEP →	-0.993	-1.214	.002	.002	3	4
PANCREAS	PSME2 →	-0.701	-1.048	.004	.009	3	4
PANCREAS	TAGLN2 →	-1.210	-1.132	<.001	.002	3	4
LUNG_SCLC	NCL →	-0.812	-1.112	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KRTCAP2 by Negative regulation of dendritic cell apoptotic process activity — LIVER

Explore this box plot interactively →