Negative regulation of interleukin-1-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-1-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A12, ATF7IP_S113, and VNN2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-1-mediated signaling pathway activity versus S100A12 in LUAD (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	S100A12 →	+1.493	+0.135	<.001	<.001	3	8
GBM	ATF7IP_S113 →	-0.647	-0.119	<.001	<.001	3	8
COAD	VNN2 →	+1.265	+0.052	<.001	<.001	3	8
GBM	AMPD3 →	+0.583	+0.154	<.001	<.001	3	8
COAD	ITGAM →	+0.826	+0.061	<.001	<.001	3	8
GBM	PGLYRP1 →	+1.014	+0.122	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000660 vs S100A12 — LUAD

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