Negative regulation of interleukin-1-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of interleukin-1-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4F, COTL1, and ROBO2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-1-mediated signaling pathway activity versus PLA2G4F in PDAC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLA2G4F →	-0.449	-0.193	.001	.009	3	5
BRCA	COTL1 →	+0.583	+0.600	.005	.005	3	4
BRCA	ROBO2 →	-0.820	-0.760	.008	.001	2	5
OV	ADAM1B →	-0.282	-0.362	.001	.009	3	4
COAD	AZGP1 →	-0.692	-0.501	.009	.004	3	3
COAD	NCF1C →	+0.559	+0.635	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000660 vs PLA2G4F — PDAC

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