Negative regulation of interleukin-1-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-1-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR21, IL1RN, and ZNF675, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MIR21 grouped by Negative regulation of interleukin-1-mediated signaling pathway-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MIR21 →	-0.402	-1.890	.004	.003	3	10
CNS	IL1RN →	-0.288	-0.932	<.001	<.001	3	9
PANCREAS	ZNF675 →	-0.270	-1.495	.001	.005	2	7
UPPER_AERODIGESTIVE_TRACT	OTUD4 →	-0.480	-2.222	.001	<.001	2	6
PANCREAS	IL1R2 →	-0.176	-1.900	<.001	<.001	3	5
LIVER	ABCA4 →	+0.251	+1.095	.004	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIR21 by Negative regulation of interleukin-1-mediated signaling pathway activity — URINARY_TRACT

Explore this box plot interactively →