Negative regulation of interleukin-1-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-1-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPX1, ACVR1, and TTC31, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPX1 grouped by Negative regulation of interleukin-1-mediated signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPX1 →	+0.236	+0.301	.001	.001	3	3
BLOOD_Leukemia	ACVR1 →	-0.212	-0.408	<.001	.002	3	3
LUNG_SCLC	TTC31 →	+0.088	+0.485	.002	<.001	3	3
LARGE_INTESTINE	LTBP2 →	+0.272	+0.598	.001	.002	3	3
LUNG_SCLC	RPP30 →	+0.529	+0.614	.008	<.001	3	3
LUNG_NSCLC_LUAD	SLC28A3 →	+0.195	+0.295	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPX1 by Negative regulation of interleukin-1-mediated signaling pathway activity — LUNG_NSCLC_LUAD

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