Negative regulation of interleukin-1-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of interleukin-1-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DTNB, MOGAT3, and HESX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of interleukin-1-mediated signaling pathway activity versus DTNB in LARGE_INTESTINE (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DTNB →	-0.954	-0.483	.001	<.001	3	4
LARGE_INTESTINE	MOGAT3 →	+2.627	+0.440	<.001	<.001	3	3
BLOOD_Leukemia	HESX1 →	-1.521	-0.339	.003	.003	3	3
CNS	ADGRL3 →	+1.860	+0.395	.004	.005	3	3
OESOPHAGUS	METTL15 →	-0.706	-0.481	.005	.009	3	3
OESOPHAGUS	KRT13 →	-4.930	-0.661	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000660 vs DTNB — LARGE_INTESTINE

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